Belly Fat is Destroying Your Mental Health
From Nick Norwitz MD PhD - Metabolic Health & Longevity · 19:27
Show by Nick Norwitz MD PhD
For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/can-visceral-fat-cause-depression?r=40ekz2 Chapter*Call our service line at 815-STAY-CUR (815-782-9287) *Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2 Visceral Fat Randomized Controlled Trial Video: https://youtu.be/lDeegZ1wtAIDescription:Most people think of fat as extra weight—something cosmetic or something to “burn off.” But new science is showing something far more profound: visceral fat is an endocrine organ that sends biochemical messages across the entire body, including directly into the brain. And those messages can change mood, increase stress sensitivity, and even promote depression.In this video, we break down a brand-new study revealing how visceral fat releases tiny molecular packages called extracellular vesicles. Inside those vesicles is a specific microRNA—a signal that can cross the blood-brain barrier, impair neurons in the hippocampus, lower BDNF, and induce depression-like behavior in animal models. This emerging research provides a mechanistic explanation for why obesity and depression are so tightly linked, why mood disorders often worsen with metabolic disease, and why improving metabolic health may improve mental health. Finally, we explore what you can do today—how reducing visceral fat may lower miR-145-5p, improve brain resilience, and break the vicious metabolic–mood loop. Your metabolism and your mind are not separate systems. They are one.Chapters:0:00 – Visceral Fat: More Than Storage1:03 – Can Fat Cause Depression? New Biology2:26 – The Obesity–Depression Loop3:32 – Mechanism: How Visceral Fat Sends Signals to the Brain5:07 – miR-145-5p: The Molecular “Letter” Driving Depression9:19 – What You Can Do: Reducing Visceral Fat to Protect Brain Health#visceralfat #depression #metabolichealth #extracellularvesicles #microRNA #brainhealth #inflammation #mentalhealth #obesityresearch #healthscience #NickNorwitz #StayCuriousMetabolism*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. Learn more about your ad choices. Visit megaphone.fm/adchoices
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