Immortality and Tumor Evolution: Partners in the Cancer Crime
From Science (Audio) · 00:57:12
Show by UCTV
Why does glioblastoma often return after treatment? Joe Costello, Ph.D., of UC San Francisco, examines two connected processes underlying this aggressive brain cancer: tumor evolution and the ability of cancer cells to keep dividing. Using three-dimensional sampling across multiple regions of brain tumors, his research investigates small populations of early ancestral cells that appear to survive treatment and may contribute to recurrence. Costello also examines how changes involving the TERT gene help tumor cells maintain their ability to divide. In laboratory and animal experiments, his team tests ways to interfere with proteins that activate TERT, while using artificial intelligence to identify additional potential targets. Although much of this research remains preliminary, it offers new insights into why glioblastoma is difficult to treat and possible directions for future therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40859]
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