1733-Frequency Encoding Regulates Intestinal Cell Fate
From Paper Talk · 00:21:07
Show by 淼淼Elva
Frequency encoding is a critical mechanism that regulates cell type composition in the small intestine. Researchers observed that the Notch target protein Hes1 oscillates dynamically, forming a distinct period gradient from fast oscillations at the crypt base to slower oscillations along the villus. By utilizing microfluidic systems to entrain these molecular oscillations, scientists demonstrated that different oscillation frequencies directly dictate cellular differentiation fates, such as promoting stem cell maintenance or broader secretory lineages. Ultimately, this biological process proves that information for cell fate specification is encoded directly within the rhythm of Notch-driven signals rather than solely through signal intensity.References:Weterings S D C, Eto H, de Leede-Scheven J D, et al. Frequency encoding regulates cell type composition in the small intestine[J]. Science, 2026, 394(6821): eadt1928.前往小宇宙评论区与主播互动
More episodes
- 1736-SLC25A34 Links Clock to Adipocyte Metabolism
- 1737-Dendritic Computation in Flexible Decision-Making
- 1738-Mammalian Biosynthesis of Elemental Sulfur
- 1734-Ceramide-Driven Colorectal Cancer Metastasis
- 1735-Golgi-Derived Vesicles Drive Mitochondrial Fusion
- 1730-Hetairos: AI for CNS Tumor Methylation Subtypes
- 1731-Lineage Identity Governs KRAS Inhibitor Resistance
- 1732-Interferon-Alpha Remodels Blood Development
- 1727-Pancreatic Adenocarcinoma Clonal and Tumor Evolution
- 1728-Stroke Drives Glioma Progression
podsearch is a free, independent podcast search engine. Read about podsearch, the privacy policy or contact us.